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STUDY REGARDING THE EFFECT OF PRUNUS SPINOSA AQUEOUS SOLUTION ON SALIVARY COTININE - MARKER OF OXIDATIVE STRESS
Abstract
Background This paper aims to assess the activity of salivary cotinine in a study group before and after the use of an aqueous solution obtained from Prunus spinosa, and also the evaluation of a possible correlation between its action and levels of salivary cotinine. Methods The study group was made of 50 volunteers: 25 volunteers that used for a week aqueous solution made from dried fruit pulp of the species Prunus spinosa and 25 volunteers who used a blank solution at the same time, evaluating the comparative results. The salivary cotinine levels were measured using NicAlert™ Saliva tests, evaluating the status declared by the smoker based upon the questionary. Results based on the questionnaires of the self-assessed smokers, 14 are constant smokers, 13 are occasional smokers, and the remaining 23 are non-smokers (passive and those not exposed to tobacco smoke). The results indicate that the aqueous solution obtained from Prunus spinosa, produced a decrease in salivary cotinine, in varying degrees, both in smokers and in non-smokers. Conclusions These preliminary results must be extended and correlated with larger studies, in order to obtain pharmaceutical preparations with inhibition effect of cotinine in the oral cavity.
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