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PHARMACOVIGILANCE OF BENZODIAZEPINES AND THEIR ROLE IN THE TREATMENT OF ANXIETY
Abstract
Anxiety affects thinking, perception and learning and it can cause distortion of perception, reducing the power of concentration and the associative and evocative memory. Anxiety is one of the most common disorders encountered in clinical practice. Anxiety disorders have a significant impact on everyday life, causing the affected person to suffer greatly. Anxiety can be perceived as an inexplicable feeling of impending doom, as an unfounded and exaggerated concern related to everyday life or as an unjustified fear when faced with a certain situation. Benzodiazepines are medicines with the largest spectrum of action at the level of the CNS, and consequently, they are among the most prescribed medicines in this field. The dynamic evolution in the field of CNS medication led to the introduction in therapy of some groups of neuroleptics, antidepressants, anxiolytics, hypnotics and sedatives. A medicine can induce beneficial effects but it can also cause side effects, hence pharmacovigilance aims to monitor the safety of medicines throughout their lifecycle. Benzodiazepines are generally, well tolerated having the advantage of a high therapeutic index, but they can in some cases cause acute poisoning (suicide, accidental poisoning), drug dependence and adverse effects.
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