Scholarly record
THE ADIPOKINES AND THE PROGRESSION OF NONALCOHOLIC FATTY LIVER DISEASE IN OBESE PATIENTS
Abstract
The purpose of the study was the evaluation of the patients suffering from obesity and nonalcoholic fatty liver disease (NAFLD) starting with anthropometric, biochemical, imaging data and the correlation of the serum level of leptin and adiponectin with the histopathological results. Material and method: we included in this study 20 men and 34 women diagnosed with nonalcoholic fatty liver disease by recent (under 6 months) hepatic biopsy, taking usual blood samples, leptin and adiponectin. Results: According to their body mass index (BMI), 32% of the patients were overweight, 68% were obese. The histological modifications were positively correlated to elevated serum levels of the triglycerides and ALT and to an elevated BMI. AST/ALT ratio 1 in the ones with disease progression. The aminotranspherases, GGT, the triglycerides and the leptin showed elevated serum levels in all patients. We found a positive correlation between the ultrasound description of the steatosis and the serum level of ALT. Adiponectin negatively correlated with the histological classification, and the leptin did not correlate with the histological modifications. Leptin positively correlated with the abdominal circumference, BMI and the ultrasound description. Conclusion: The adipokines are definitely involved in the progression of NAFLD in the obese patients.
Publication Impact Profile
Publication details
References15
. Mathurin R: La steatohepatite non alcoolique: lˈhepatologie du future gastroenterol Clin Biol 2002, 26:471 – 2.
. Neuschwander-Tetri B, Caldwell S. Non-alcoholic Steatohepatitis: Summer of an AASLD Single Topic Conference. Hepatology 2003; 37(5): 1202-1219.
. Dixon J.B, O Brien P.E, Bhatal P.S. A wider view on diagnostic criteria of nonalcoholic steatohepatitis. Gastroenterology 2002; 122: 841-842.
. Mathieson U.L, Franzen L.E, Fryden A et al. The clinical significance of slightly to moderately elevated liver transaminase values in asymptomatic patients. Scand J gastroenterology 1999;34:85-91.
. Daniel S, Ben-Menachem T, Vasudevan G et al. Prospective evolution of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 1999; 94: 3010-3014.
. Ratziu V, Girai P, Charlotte F et al. Liver fibrosis in overweight patients. Gastroenterology 2000; 118: 1117-1123.
. Garcia-Monzon C, Martin-Prerz E et al. Characterization of pathologic and prognostic factors of nonalcoholic steatohepatitis associated with obesity. J Hepatol 2000; 33: 716-724.
. Vendemiale G, Grattagliano I, Caraceni P et al. Mitochondrial oxidative injury and energy metabolism alternation in rat fatty liver: effect of nutritional status. Hepatology 2001; 33:808-815.
. Matteoni C.A, Younossi Z.M et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413-1419.
. Reid A.E. Nonalcoholic steatohepatitis. Gastroenterology 2001; 121: 710-723.
. Ueno T, Sugawara H, Sujaku IC, et al. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J Hepatol 1997; 27: 103-107.
. Lazo M, Hernaez R, Bonekamp S, Kamel I.R, Brancati F.L, Guallar E, Clark J.M. Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study. BMJ. 2011;343:d6891
. Tarantino G, Colao A, Capone D, Conca P, Tarantino M, Grimaldi E, Chianese D, Finelli C, Contaldo F, Scopacasa F. Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease. J Biol Regul Homeost Agents. 2011;25:47-56
. Nagata K, Suzuki H, Sakaguchi S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci. 2007;32:453-468
. Mirza MS. Obesity, Visceral Fat, and NAFLD: Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease. ISRN Gastroenterol. 2011;2011:592404
View or Download full articleAccess options
SWS access login
Login as SWS Scientific CommitteeLogin as SWS Scientific PartnerLogin as SWS AuthorAuthors and approved SWS contributors will read and export their own linked papers after identity matching by SWS profile, email and SGEM GlobalID.
For librarian assistance: [email protected]
Purchase Instant Access
- Article can be downloaded after successful payment.
- Article may be used according to SWS library access terms.
- Article cannot be redistributed.
