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Age, obesity, sex and previous injuries are considered to be significant risk factors for osteoarthritis. Mud is a therapeutic agent used since ancient times to treat osteoarthritis. Although extensively used, the mechanisms by which balneal therapy acts are poorly studied, sometimes we can even say that they are "full of surprises". The complexity of its biochemical composition, the rich microbial flora, the inter-relationships between its components, slow down the detection of the physiological and therapeutic e...